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What the heck are nanoparticles, micelles, and liposomes?

Hemp Marketplace Home Forums Hemp Applications What the heck are nanoparticles, micelles, and liposomes?

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    Anne Jefferson
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    Each of these structures is a way to encapsulate a drug, such as CBD, in a lipophilic (fat-loving) core with an outside layer of hydrophilic (water-loving) molecules. This outer layer forms a barrier around the CBD molecules to delay their metabolism in the human digestive system.

    Nanoparticles are tiny clusters of CBD molecules that are surrounded by a fatty acid. The lipophilic end of the fatty acid aligns with the CBD cluster and the hydrophilic end points to the outside surface. Think of this as a bicycle wheel. The CBD cluster is the wheel hub; the fatty acid is the spokes; the lipophilic end attaches to the hub and the hydrophilic end attaches to the tire rim. Nanoparticles are small enough (~1-5 x 10-7 meters) to be absorbed in the small intestine. These invisible particles remain suspended in water-based liquids, making them a great way to add CBD to drinks.

    Micelles are similar in size to nanoparticles but have a different formation and delivery processes. Like nanoparticles, micelles have an inner lipophilic core and an outer hydrophilic shell. CBD molecules, as well as terpenes and other cannabinoids, can dissolve in the inner core. Micelles aren’t necessarily round and can be cylindrical or an irregular shape. Micelles also can be formed from larger polymers and contain several layers of molecules. Surfactants form the micelle structure that solvates CBD and helps emulsify or mix the CBD into hydrophilic body fluids. An interesting feature of micelles is that they can deliver multiple therapeutic compounds to a site. The outer surfactant can be chosen to selectively interact with specific enzymes and proteins to target different types of cells.

    Liposomes are typically larger than nanoparticles and micelles. The liposome structure consists of 2 lipid bilayers with an inner aqueous solution. Think of it as a donut with the inner hole being filled with hydrophilic molecules and lipophilic or fatty molecules in the outer ring. The liposome can either fuse to a cell surface to deliver drugs or the cell, in a process known as endocytosis, can swallow the liposome. This targeted delivery of the liposome to cell walls allows it to bypass metabolism in the gastrointestinal tract.

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do_action('bbp_add_rewrite_rules'), WP_Hook->do_action, WP_Hook->apply_filters, bbPress->add_rewrite_rules, bbp_get_edit_slug, get_option [3] => 1656377003.9531 [4] => Array ( ) ) [33] => Array ( [0] => SELECT option_value FROM wp_options WHERE option_name = 'nonce_key' LIMIT 1 [1] => 0.00020599365234375 [2] => require('wp-blog-header.php'), require_once('wp-load.php'), require_once('wp-config.php'), require_once('wp-settings.php'), do_action('init'), WP_Hook->do_action, WP_Hook->apply_filters, WP_Scripts->init, do_action_ref_array('wp_default_scripts'), WP_Hook->do_action, WP_Hook->apply_filters, wp_default_scripts, wp_create_nonce, wp_hash, wp_salt, get_site_option, get_network_option, get_option [3] => 1656377003.9682 [4] => Array ( ) ) [34] => Array ( [0] => SELECT option_value FROM wp_options WHERE option_name = 'nonce_salt' LIMIT 1 [1] => 0.00017404556274414 [2] => require('wp-blog-header.php'), require_once('wp-load.php'), require_once('wp-config.php'), require_once('wp-settings.php'), do_action('init'), WP_Hook->do_action, WP_Hook->apply_filters, WP_Scripts->init, do_action_ref_array('wp_default_scripts'), WP_Hook->do_action, WP_Hook->apply_filters, wp_default_scripts, wp_create_nonce, wp_hash, wp_salt, get_site_option, get_network_option, get_option [3] => 1656377003.9686 [4] => Array ( ) ) [35] => Array ( [0] => SELECT option_value FROM wp_options WHERE option_name = 'ghostpool_sidebars' LIMIT 1 [1] => 0.00019717216491699 [2] => require('wp-blog-header.php'), require_once('wp-load.php'), require_once('wp-config.php'), require_once('wp-settings.php'), do_action('init'), WP_Hook->do_action, WP_Hook->apply_filters, wp_widgets_init, do_action('widgets_init'), WP_Hook->do_action, WP_Hook->apply_filters, ghostpool_widgets_init, get_option [3] => 1656377004.011 [4] => Array ( ) ) [36] => Array ( [0] => SET SQL_BIG_SELECTS=1 [1] => 0.00014400482177734 [2] => require('wp-blog-header.php'), require_once('wp-load.php'), require_once('wp-config.php'), require_once('wp-settings.php'), do_action('init'), WP_Hook->do_action, WP_Hook->apply_filters, AWPCP->init [3] => 1656377004.0559 [4] => Array ( ) ) [37] => Array ( [0] => SELECT option_value FROM wp_options WHERE option_name = 'awpcp-store-browse-categories-page-information' LIMIT 1 [1] => 0.00022506713867188 [2] => require('wp-blog-header.php'), require_once('wp-load.php'), require_once('wp-config.php'), require_once('wp-settings.php'), do_action('init'), WP_Hook->do_action, WP_Hook->apply_filters, AWPCP->init, get_option [3] => 1656377004.0589 [4] => Array ( ) ) [38] => Array ( [0] => SELECT option_value FROM wp_options WHERE option_name = 'awpcp-maybe-fix-browse-categories-page-information' LIMIT 1 [1] => 0.00013494491577148 [2] => require('wp-blog-header.php'), require_once('wp-load.php'), require_once('wp-config.php'), require_once('wp-settings.php'), do_action('init'), WP_Hook->do_action, WP_Hook->apply_filters, AWPCP->init, get_option [3] => 1656377004.0675 [4] => Array ( ) ) [39] => Array ( [0] => SELECT * FROM wp_awpcp_extra_fields WHERE field_name <> '' ORDER BY weight ASC, field_id ASC [1] => 0.00028204917907715 [2] => require('wp-blog-header.php'), require_once('wp-load.php'), require_once('wp-config.php'), require_once('wp-settings.php'), do_action('init'), WP_Hook->do_action, WP_Hook->apply_filters, AWPCP_Module->setup_module, AWPCP_ExtraFieldsModule->module_setup, awpcp_extra_fields_search_listings_widget_integration, awpcp_get_extra_fields [3] => 1656377004.0689 [4] => Array ( ) ) [40] => Array ( [0] => SELECT * FROM wp_awpcp_extra_fields WHERE field_name <> '' ORDER BY weight ASC, field_id ASC [1] => 0.0002448558807373 [2] => require('wp-blog-header.php'), require_once('wp-load.php'), require_once('wp-config.php'), require_once('wp-settings.php'), do_action('init'), WP_Hook->do_action, WP_Hook->apply_filters, AWPCP_Module->setup_module, AWPCP_ExtraFieldsModule->module_setup, awpcp_extra_fields_search_listings_widget_integration, AWPCP_ExtraFieldsSearchWidgetIntegration->__construct, awpcp_get_extra_fields [3] => 1656377004.0698 [4] => Array ( ) ) [41] => Array ( [0] => SELECT * FROM wp_posts WHERE ID = 23 LIMIT 1 [1] => 0.0082478523254395 [2] => require('wp-blog-header.php'), require_once('wp-load.php'), require_once('wp-config.php'), require_once('wp-settings.php'), do_action('init'), WP_Hook->do_action, WP_Hook->apply_filters, AWPCP_SettingsManager->register_settings, do_action('awpcp_register_settings'), WP_Hook->do_action, WP_Hook->apply_filters, AWPCP_ListingsSettings->register_settings, AWPCP_ListingsSettings->register_seo_settings, AWPCP_ListingsSettings->register_url_settings, awpcp_get_page_by_ref, get_post, WP_Post::get_instance [3] => 1656377004.0997 [4] => Array ( ) ) [42] => Array ( [0] => SELECT * FROM wp_posts WHERE ID = 22 LIMIT 1 [1] => 0.00019288063049316 [2] => require('wp-blog-header.php'), require_once('wp-load.php'), require_once('wp-config.php'), require_once('wp-settings.php'), do_action('init'), WP_Hook->do_action, WP_Hook->apply_filters, AWPCP_SettingsManager->register_settings, do_action('awpcp_register_settings'), WP_Hook->do_action, WP_Hook->apply_filters, AWPCP_ListingsSettings->register_settings, AWPCP_ListingsSettings->register_seo_settings, AWPCP_ListingsSettings->register_url_settings, awpcp_get_page_link, get_page_uri, WP_Post->__get, get_post_ancestors, get_post, WP_Post::get_instance [3] => 1656377004.1083 [4] => Array ( ) ) [43] => Array ( [0] => SELECT option_value FROM wp_options WHERE option_name = 'awpcp-installed' LIMIT 1 [1] => 0.00016999244689941 [2] => require('wp-blog-header.php'), require_once('wp-load.php'), require_once('wp-config.php'), require_once('wp-settings.php'), do_action('init'), WP_Hook->do_action, WP_Hook->apply_filters, AWPCP->first_time_verifications, get_option [3] => 1656377004.1347 [4] => Array ( ) ) [44] => Array ( [0] => SELECT wp_posts.* FROM wp_posts INNER JOIN wp_postmeta ON ( wp_posts.ID = wp_postmeta.post_id ) WHERE 1=1 AND ( wp_postmeta.meta_key = 'order' ) AND wp_posts.post_type = 'bb_device' AND ((wp_posts.post_status = 'publish')) GROUP BY wp_posts.ID ORDER BY wp_postmeta.meta_value ASC [1] => 0.012421846389771 [2] => require('wp-blog-header.php'), require_once('wp-load.php'), require_once('wp-config.php'), require_once('wp-settings.php'), do_action('init'), WP_Hook->do_action, WP_Hook->apply_filters, BESTBUG_RPPRO_CLASS->load_devices, get_posts, WP_Query->query, WP_Query->get_posts [3] => 1656377004.1361 [4] => Array ( ) ) [45] => Array ( [0] => SELECT post_id, meta_key, meta_value FROM wp_postmeta WHERE post_id IN (100004846,100004847,100004848,100004849,100004850) ORDER BY meta_id ASC [1] => 0.00027298927307129 [2] => require('wp-blog-header.php'), require_once('wp-load.php'), require_once('wp-config.php'), require_once('wp-settings.php'), do_action('init'), WP_Hook->do_action, WP_Hook->apply_filters, BESTBUG_RPPRO_CLASS->load_devices, get_posts, WP_Query->query, WP_Query->get_posts, update_post_caches, update_postmeta_cache, update_meta_cache [3] => 1656377004.1491 [4] => Array ( ) ) [46] => Array ( [0] => SELECT option_value FROM wp_options WHERE option_name = 'wp_super_cache_disabled' LIMIT 1 [1] => 0.00014877319335938 [2] => require('wp-blog-header.php'), require_once('wp-load.php'), require_once('wp-config.php'), require_once('wp-settings.php'), do_action('init'), WP_Hook->do_action, WP_Hook->apply_filters, wp_super_cache_override_on_flag, get_option [3] => 1656377004.1497 [4] => Array ( ) ) [47] => Array ( [0] => SELECT * FROM wp_posts WHERE ID = 94 LIMIT 1 [1] => 0.00019502639770508 [2] => require('wp-blog-header.php'), require_once('wp-load.php'), require_once('wp-config.php'), require_once('wp-settings.php'), do_action('init'), WP_Hook->do_action, WP_Hook->apply_filters, bp_init, do_action('bp_init'), WP_Hook->do_action, WP_Hook->apply_filters, bp_core_set_uri_globals, bp_core_get_directory_pages, bp_core_get_directory_page_ids, get_post_status, get_post, WP_Post::get_instance [3] => 1656377004.1912 [4] => Array ( ) ) [48] => Array ( [0] => SELECT * FROM wp_posts WHERE ID = 466 LIMIT 1 [1] => 0.00016999244689941 [2] => require('wp-blog-header.php'), require_once('wp-load.php'), require_once('wp-config.php'), require_once('wp-settings.php'), do_action('init'), WP_Hook->do_action, WP_Hook->apply_filters, bp_init, do_action('bp_init'), WP_Hook->do_action, WP_Hook->apply_filters, bp_core_set_uri_globals, bp_core_get_directory_pages, bp_core_get_directory_page_ids, get_post_status, get_post, WP_Post::get_instance [3] => 1656377004.1916 [4] => Array ( ) ) [49] => Array ( [0] => SELECT * FROM wp_posts WHERE ID = 100000004 LIMIT 1 [1] => 0.00017714500427246 [2] => require('wp-blog-header.php'), require_once('wp-load.php'), require_once('wp-config.php'), require_once('wp-settings.php'), do_action('init'), WP_Hook->do_action, WP_Hook->apply_filters, bp_init, do_action('bp_init'), WP_Hook->do_action, WP_Hook->apply_filters, bp_core_set_uri_globals, bp_core_get_directory_pages, bp_core_get_directory_page_ids, get_post_status, get_post, WP_Post::get_instance [3] => 1656377004.1921 [4] => Array ( ) ) [50] => Array ( [0] => SELECT * FROM wp_posts WHERE ID = 117 LIMIT 1 [1] => 0.00020408630371094 [2] => require('wp-blog-header.php'), require_once('wp-load.php'), require_once('wp-config.php'), require_once('wp-settings.php'), do_action('init'), WP_Hook->do_action, WP_Hook->apply_filters, bp_init, do_action('bp_init'), WP_Hook->do_action, WP_Hook->apply_filters, bp_core_set_uri_globals, bp_core_get_directory_pages, bp_core_get_directory_page_ids, get_post_status, get_post, WP_Post::get_instance [3] => 1656377004.1925 [4] => Array ( ) ) [51] => Array ( [0] => SELECT * FROM wp_posts WHERE ID = 468 LIMIT 1 [1] => 0.012383937835693 [2] => require('wp-blog-header.php'), require_once('wp-load.php'), require_once('wp-config.php'), require_once('wp-settings.php'), do_action('init'), WP_Hook->do_action, WP_Hook->apply_filters, bp_init, do_action('bp_init'), WP_Hook->do_action, WP_Hook->apply_filters, bp_core_set_uri_globals, bp_core_get_directory_pages, bp_core_get_directory_page_ids, get_post_status, get_post, WP_Post::get_instance [3] => 1656377004.193 [4] => Array ( ) ) [52] => Array ( [0] => SELECT * FROM wp_posts WHERE ID = 469 LIMIT 1 [1] => 0.00017118453979492 [2] => require('wp-blog-header.php'), require_once('wp-load.php'), require_once('wp-config.php'), require_once('wp-settings.php'), do_action('init'), WP_Hook->do_action, WP_Hook->apply_filters, bp_init, do_action('bp_init'), WP_Hook->do_action, WP_Hook->apply_filters, bp_core_set_uri_globals, bp_core_get_directory_pages, bp_core_get_directory_page_ids, get_post_status, get_post, WP_Post::get_instance [3] => 1656377004.2056 [4] => Array ( ) ) [53] => Array ( [0] => SELECT * FROM wp_posts WHERE (post_type = 'page' AND post_status = 'publish') ORDER BY wp_posts.post_title ASC [1] => 0.00064492225646973 [2] => require('wp-blog-header.php'), require_once('wp-load.php'), require_once('wp-config.php'), require_once('wp-settings.php'), do_action('init'), WP_Hook->do_action, WP_Hook->apply_filters, bp_init, do_action('bp_init'), WP_Hook->do_action, WP_Hook->apply_filters, bp_core_set_uri_globals, bp_core_get_directory_pages, bp_core_get_directory_page_ids, apply_filters('bp_core_get_directory_page_ids'), WP_Hook->apply_filters, bps_custom_directory, bps_is_directory, bps_directories, get_pages [3] => 1656377004.2067 [4] => Array ( ) ) [54] => Array ( [0] => SELECT ID, post_name, post_parent, post_title FROM wp_posts WHERE ID IN (94,466,117,468,469) AND post_status = 'publish' [1] => 0.00024199485778809 [2] => require('wp-blog-header.php'), require_once('wp-load.php'), require_once('wp-config.php'), require_once('wp-settings.php'), do_action('init'), WP_Hook->do_action, WP_Hook->apply_filters, bp_init, do_action('bp_init'), WP_Hook->do_action, WP_Hook->apply_filters, bp_core_set_uri_globals, bp_core_get_directory_pages [3] => 1656377004.2202 [4] => Array ( ) ) [55] => Array ( [0] => SELECT option_name AS name, option_value AS value FROM wp_options WHERE option_name IN ( 'bp-deactivated-components', 'bp-xprofile-base-group-name', 'bp-xprofile-fullname-field-name', 'bp-blogs-first-install', 'bp-disable-profile-sync', 'hide-loggedout-adminbar', 'bp-disable-avatar-uploads', 'bp-disable-cover-image-uploads', 'bp-disable-group-avatar-uploads', 'bp-disable-group-cover-image-uploads', 'bp-disable-account-deletion', 'bp-disable-blogforum-comments', '_bp_theme_package_id', 'bp-emails-unsubscribe-salt', 'bp_restrict_group_creation', '_bp_enable_akismet', '_bp_enable_heartbeat_refresh', '_bp_force_buddybar', '_bp_retain_bp_default', '_bp_ignore_deprecated_code', 'widget_bp_core_login_widget', 'widget_bp_core_members_widget', 'widget_bp_core_whos_online_widget', 'widget_bp_core_recently_active_widget', 'widget_bp_groups_widget', 'widget_bp_messages_sitewide_notices_widget', 'registration', 'avatar_default' ) [1] => 0.00051116943359375 [2] => require('wp-blog-header.php'), require_once('wp-load.php'), require_once('wp-config.php'), require_once('wp-settings.php'), do_action('init'), WP_Hook->do_action, WP_Hook->apply_filters, bp_init, do_action('bp_init'), WP_Hook->do_action, WP_Hook->apply_filters, bp_core_set_avatar_constants, bp_attachments_get_max_upload_file_size, bp_core_get_root_option, bp_core_get_root_options [3] => 1656377004.221 [4] => Array ( ) ) [56] => Array ( [0] => SELECT COUNT( DISTINCT( p.ID ) ) as count, p.post_status as status, t.term_taxonomy_id as term_id FROM wp_posts p LEFT JOIN wp_term_relationships t ON( p.ID = t.object_id ) WHERE p.post_type = 'bp_attachment' GROUP BY p.post_status,t.term_taxonomy_id [1] => 0.03000807762146 [2] => require('wp-blog-header.php'), require_once('wp-load.php'), require_once('wp-config.php'), require_once('wp-settings.php'), do_action('init'), WP_Hook->do_action, WP_Hook->apply_filters, bp_init, do_action('bp_init'), WP_Hook->do_action, WP_Hook->apply_filters, bp_setup_nav, do_action('bp_setup_nav'), WP_Hook->do_action, WP_Hook->apply_filters, BP_Attachments_Component->setup_nav, BP_Attachments::count [3] => 1656377004.2254 [4] => Array ( ) ) [57] => Array ( [0] => SELECT option_value FROM wp_options WHERE option_name = 'bb_rppro_list_attrs' LIMIT 1 [1] => 0.00016522407531738 [2] => require('wp-blog-header.php'), require_once('wp-load.php'), require_once('wp-config.php'), require_once('wp-settings.php'), do_action('init'), WP_Hook->do_action, WP_Hook->apply_filters, BESTBUG_RPPRO_TABS->tabs, bb_option, get_option [3] => 1656377004.2825 [4] => Array ( ) ) [58] => Array ( [0] => SELECT option_value FROM wp_options WHERE option_name = 'bb_rppro_selector' LIMIT 1 [1] => 0.00013899803161621 [2] => require('wp-blog-header.php'), require_once('wp-load.php'), require_once('wp-config.php'), require_once('wp-settings.php'), do_action('init'), WP_Hook->do_action, WP_Hook->apply_filters, BESTBUG_RPPRO_TABS->tabs, bb_option, get_option [3] => 1656377004.2842 [4] => Array ( ) ) [59] => Array ( [0] => SELECT option_value FROM wp_options WHERE option_name = 'wpb_js_less_version' LIMIT 1 [1] => 0.00018596649169922 [2] => require('wp-blog-header.php'), require_once('wp-load.php'), require_once('wp-config.php'), require_once('wp-settings.php'), do_action('init'), WP_Hook->do_action, WP_Hook->apply_filters, Vc_Manager->init, do_action('vc_before_init'), WP_Hook->do_action, WP_Hook->apply_filters, vc_check_for_custom_css_build, Vc_Settings->getCustomCssVersion, get_option [3] => 1656377006.1011 [4] => Array ( ) ) [60] => Array ( [0] => SELECT option_value FROM wp_options WHERE option_name = 'vc_automapped_shortcodes' LIMIT 1 [1] => 0.00018811225891113 [2] => require('wp-blog-header.php'), require_once('wp-load.php'), require_once('wp-config.php'), require_once('wp-settings.php'), do_action('init'), WP_Hook->do_action, WP_Hook->apply_filters, Vc_Manager->init, Vc_Automapper::map, Vc_Automap_Model::findAll, Vc_Automap_Model::loadOptionData, get_option [3] => 1656377006.287 [4] => Array ( ) ) [61] => Array ( [0] => SELECT option_value FROM wp_options WHERE option_name = 'awpcp_plugin_integrations' LIMIT 1 [1] => 0.00018715858459473 [2] => require('wp-blog-header.php'), require_once('wp-load.php'), require_once('wp-config.php'), require_once('wp-settings.php'), do_action('init'), WP_Hook->do_action, WP_Hook->apply_filters, AWPCP_Plugin_Integrations->load_plugin_integrations, AWPCP_Plugin_Integrations->get_enabled_plugin_integrations, get_option [3] => 1656377006.4264 [4] => Array ( ) ) [62] => Array ( [0] => SELECT option_value FROM wp_options WHERE option_name = 'awpcp-store-categories-order-as-term-meta' LIMIT 1 [1] => 0.0083861351013184 [2] => require('wp-blog-header.php'), require_once('wp-load.php'), require_once('wp-config.php'), require_once('wp-settings.php'), do_action('wp_loaded'), WP_Hook->do_action, WP_Hook->apply_filters, AWPCP->wp_loaded, AWPCP_Router->configure_routes, do_action('awpcp-configure-routes'), WP_Hook->do_action, WP_Hook->apply_filters, AWPCP_AdminPanel->configure_routes, AWPCP_Upgrade_Tasks_Manager->has_pending_tasks, AWPCP_Upgrade_Tasks_Manager->get_pending_tasks, AWPCP_Upgrade_Tasks_Manager->is_upgrade_task_enabled, get_option [3] => 1656377006.4284 [4] => Array ( ) ) [63] => Array ( [0] => SELECT option_value FROM wp_options WHERE option_name = 'awpcp-store-media-as-attachments-upgrade-task-handler' LIMIT 1 [1] => 0.00015902519226074 [2] => require('wp-blog-header.php'), require_once('wp-load.php'), require_once('wp-config.php'), require_once('wp-settings.php'), do_action('wp_loaded'), WP_Hook->do_action, WP_Hook->apply_filters, AWPCP->wp_loaded, AWPCP_Router->configure_routes, do_action('awpcp-configure-routes'), WP_Hook->do_action, WP_Hook->apply_filters, AWPCP_AdminPanel->configure_routes, AWPCP_Upgrade_Tasks_Manager->has_pending_tasks, AWPCP_Upgrade_Tasks_Manager->get_pending_tasks, AWPCP_Upgrade_Tasks_Manager->is_upgrade_task_enabled, get_option [3] => 1656377006.437 [4] => Array ( ) ) [64] => Array ( [0] => SELECT option_value FROM wp_options WHERE option_name = 'awpcp-generate-thumbnails-for-migrated-media' LIMIT 1 [1] => 0.00011706352233887 [2] => require('wp-blog-header.php'), require_once('wp-load.php'), require_once('wp-config.php'), require_once('wp-settings.php'), do_action('wp_loaded'), WP_Hook->do_action, WP_Hook->apply_filters, AWPCP->wp_loaded, AWPCP_Router->configure_routes, do_action('awpcp-configure-routes'), WP_Hook->do_action, WP_Hook->apply_filters, AWPCP_AdminPanel->configure_routes, AWPCP_Upgrade_Tasks_Manager->has_pending_tasks, AWPCP_Upgrade_Tasks_Manager->get_pending_tasks, AWPCP_Upgrade_Tasks_Manager->is_upgrade_task_enabled, get_option [3] => 1656377006.4374 [4] => Array ( ) ) [65] => Array ( [0] => SELECT option_value FROM wp_options WHERE option_name = 'awpcp-add-missing-is-paid-meta' LIMIT 1 [1] => 0.0001070499420166 [2] => require('wp-blog-header.php'), require_once('wp-load.php'), require_once('wp-config.php'), require_once('wp-settings.php'), do_action('wp_loaded'), WP_Hook->do_action, WP_Hook->apply_filters, AWPCP->wp_loaded, AWPCP_Router->configure_routes, do_action('awpcp-configure-routes'), WP_Hook->do_action, WP_Hook->apply_filters, AWPCP_AdminPanel->configure_routes, AWPCP_Upgrade_Tasks_Manager->has_pending_tasks, AWPCP_Upgrade_Tasks_Manager->get_pending_tasks, AWPCP_Upgrade_Tasks_Manager->is_upgrade_task_enabled, get_option [3] => 1656377006.4377 [4] => Array ( ) ) [66] => Array ( [0] => SELECT option_value FROM wp_options WHERE option_name = 'awpcp-add-missing-views-meta' LIMIT 1 [1] => 0.00010395050048828 [2] => require('wp-blog-header.php'), require_once('wp-load.php'), require_once('wp-config.php'), require_once('wp-settings.php'), do_action('wp_loaded'), WP_Hook->do_action, WP_Hook->apply_filters, AWPCP->wp_loaded, AWPCP_Router->configure_routes, do_action('awpcp-configure-routes'), WP_Hook->do_action, WP_Hook->apply_filters, AWPCP_AdminPanel->configure_routes, AWPCP_Upgrade_Tasks_Manager->has_pending_tasks, AWPCP_Upgrade_Tasks_Manager->get_pending_tasks, AWPCP_Upgrade_Tasks_Manager->is_upgrade_task_enabled, get_option [3] => 1656377006.438 [4] => Array ( ) ) [67] => Array ( [0] => SELECT option_value FROM wp_options WHERE option_name = 'awpcp-update-most-recent-date' LIMIT 1 [1] => 0.00010299682617188 [2] => require('wp-blog-header.php'), require_once('wp-load.php'), require_once('wp-config.php'), require_once('wp-settings.php'), do_action('wp_loaded'), WP_Hook->do_action, WP_Hook->apply_filters, AWPCP->wp_loaded, AWPCP_Router->configure_routes, do_action('awpcp-configure-routes'), WP_Hook->do_action, WP_Hook->apply_filters, AWPCP_AdminPanel->configure_routes, AWPCP_Upgrade_Tasks_Manager->has_pending_tasks, AWPCP_Upgrade_Tasks_Manager->get_pending_tasks, AWPCP_Upgrade_Tasks_Manager->is_upgrade_task_enabled, get_option [3] => 1656377006.4383 [4] => Array ( ) ) [68] => Array ( [0] => SELECT option_value FROM wp_options WHERE option_name = 'awpcp-add-missing-categories-order' LIMIT 1 [1] => 0.00010204315185547 [2] => require('wp-blog-header.php'), require_once('wp-load.php'), require_once('wp-config.php'), require_once('wp-settings.php'), do_action('wp_loaded'), WP_Hook->do_action, WP_Hook->apply_filters, AWPCP->wp_loaded, AWPCP_Router->configure_routes, do_action('awpcp-configure-routes'), WP_Hook->do_action, WP_Hook->apply_filters, AWPCP_AdminPanel->configure_routes, AWPCP_Upgrade_Tasks_Manager->has_pending_tasks, AWPCP_Upgrade_Tasks_Manager->get_pending_tasks, AWPCP_Upgrade_Tasks_Manager->is_upgrade_task_enabled, get_option [3] => 1656377006.4386 [4] => Array ( ) ) [69] => Array ( [0] => SELECT option_value FROM wp_options WHERE option_name = 'awpcp-add-contact-phone-number-digits' LIMIT 1 [1] => 0.00010180473327637 [2] => require('wp-blog-header.php'), require_once('wp-load.php'), require_once('wp-config.php'), require_once('wp-settings.php'), do_action('wp_loaded'), WP_Hook->do_action, WP_Hook->apply_filters, AWPCP->wp_loaded, AWPCP_Router->configure_routes, do_action('awpcp-configure-routes'), WP_Hook->do_action, WP_Hook->apply_filters, AWPCP_AdminPanel->configure_routes, AWPCP_Upgrade_Tasks_Manager->has_pending_tasks, AWPCP_Upgrade_Tasks_Manager->get_pending_tasks, AWPCP_Upgrade_Tasks_Manager->is_upgrade_task_enabled, get_option [3] => 1656377006.4389 [4] => Array ( ) ) [70] => Array ( [0] => SELECT option_value FROM wp_options WHERE option_name = 'awpcp-region-control-update-ad-count' LIMIT 1 [1] => 0.00014805793762207 [2] => require('wp-blog-header.php'), require_once('wp-load.php'), require_once('wp-config.php'), require_once('wp-settings.php'), do_action('wp_loaded'), WP_Hook->do_action, WP_Hook->apply_filters, AWPCP->wp_loaded, AWPCP_Router->configure_routes, do_action('awpcp-configure-routes'), WP_Hook->do_action, WP_Hook->apply_filters, AWPCP_RegionControlRouter->configure_routes, get_option [3] => 1656377006.4531 [4] => Array ( ) ) [71] => Array ( [0] => SELECT wp_posts.* FROM wp_posts WHERE 1=1 AND wp_posts.post_name = 'what-the-heck-are-nanoparticles-micelles-and-liposomes' AND wp_posts.post_type = 'topic' ORDER BY wp_posts.post_date DESC [1] => 0.033007860183716 [2] => require('wp-blog-header.php'), wp, WP->main, WP->query_posts, WP_Query->query, WP_Query->get_posts [3] => 1656377015.4687 [4] => Array ( ) ) [72] => Array ( [0] => SELECT t.*, tt.*, tr.object_id FROM wp_terms AS t INNER JOIN wp_term_taxonomy AS tt ON t.term_id = tt.term_id INNER JOIN wp_term_relationships AS tr ON tr.term_taxonomy_id = tt.term_taxonomy_id WHERE tt.taxonomy IN ('topic-tag') AND tr.object_id IN (100000681) ORDER BY t.name ASC [1] => 0.016139984130859 [2] => require('wp-blog-header.php'), wp, WP->main, WP->query_posts, WP_Query->query, WP_Query->get_posts, update_post_caches, update_object_term_cache, wp_get_object_terms, get_terms, WP_Term_Query->query, WP_Term_Query->get_terms [3] => 1656377015.5023 [4] => Array ( ) ) [73] => Array ( [0] => SELECT post_id, meta_key, meta_value FROM wp_postmeta WHERE post_id IN (100000681) ORDER BY meta_id ASC [1] => 0.01472806930542 [2] => require('wp-blog-header.php'), wp, WP->main, WP->query_posts, WP_Query->query, WP_Query->get_posts, update_post_caches, update_postmeta_cache, update_meta_cache [3] => 1656377015.5191 [4] => Array ( ) ) [74] => Array ( [0] => SELECT * FROM wp_posts WHERE ID = 100000497 LIMIT 1 [1] => 0.00015902519226074 [2] => require('wp-blog-header.php'), require_once('wp-includes/template-loader.php'), do_action('template_redirect'), WP_Hook->do_action, WP_Hook->apply_filters, bbp_template_redirect, do_action('bbp_template_redirect'), WP_Hook->do_action, WP_Hook->apply_filters, bbp_forum_enforce_hidden, bbp_is_forum_hidden, bbp_is_forum_visibility, bbp_get_forum_visibility, get_post_status, get_post, WP_Post::get_instance [3] => 1656377015.5369 [4] => Array ( ) ) [75] => Array ( [0] => SELECT option_value FROM wp_options WHERE option_name = 'awpcp-browse-categories-page-information' LIMIT 1 [1] => 0.0001530647277832 [2] => require('wp-blog-header.php'), require_once('wp-includes/template-loader.php'), do_action('template_redirect'), WP_Hook->do_action, WP_Hook->apply_filters, AWPCP_Browse_Categories_Page_Redirection_Handler->maybe_redirect, get_option [3] => 1656377015.5536 [4] => Array ( ) ) [76] => Array ( [0] => SELECT option_value FROM wp_options WHERE option_name = 'wpb_js_use_custom' LIMIT 1 [1] => 0.00018095970153809 [2] => require('wp-blog-header.php'), require_once('wp-includes/template-loader.php'), do_action('template_redirect'), WP_Hook->do_action, WP_Hook->apply_filters, Vc_Base->frontCss, Vc_Settings::get, get_option [3] => 1656377015.5871 [4] => Array ( ) ) [77] => Array ( [0] => SELECT * FROM wp_users WHERE ID = '4659' LIMIT 1 [1] => 0.017634868621826 [2] => require('wp-blog-header.php'), require_once('wp-includes/template-loader.php'), apply_filters('template_include'), WP_Hook->apply_filters, bbp_template_include, apply_filters('bbp_template_include'), WP_Hook->apply_filters, bbp_template_include_theme_compat, BBP_Shortcodes->display_topic, BBP_Shortcodes->unset_globals, wp_reset_postdata, WP_Query->reset_postdata, WP_Query->setup_postdata, WP_Query->generate_postdata, get_userdata, get_user_by, WP_User::get_data_by [3] => 1656377015.6254 [4] => Array ( ) ) [78] => Array ( [0] => SELECT user_id, meta_key, meta_value FROM wp_usermeta WHERE user_id IN (4659) ORDER BY umeta_id ASC [1] => 0.00027298927307129 [2] => require('wp-blog-header.php'), require_once('wp-includes/template-loader.php'), apply_filters('template_include'), WP_Hook->apply_filters, bbp_template_include, apply_filters('bbp_template_include'), WP_Hook->apply_filters, bbp_template_include_theme_compat, BBP_Shortcodes->display_topic, BBP_Shortcodes->unset_globals, wp_reset_postdata, WP_Query->reset_postdata, WP_Query->setup_postdata, WP_Query->generate_postdata, get_userdata, get_user_by, WP_User->init, WP_User->for_site, WP_User->get_caps_data, get_user_meta, get_metadata, get_metadata_raw, update_meta_cache [3] => 1656377015.6435 [4] => Array ( ) ) [79] => Array ( [0] => SELECT ID, post_name, post_parent, post_type FROM wp_posts WHERE post_name IN ('forums') AND post_type IN ('page','attachment') [1] => 0.00023102760314941 [2] => require('wp-blog-header.php'), require_once('wp-includes/template-loader.php'), apply_filters('template_include'), WP_Hook->apply_filters, bbp_template_include, apply_filters('bbp_template_include'), WP_Hook->apply_filters, bbp_template_include_theme_compat, BBP_Shortcodes->display_topic, bbp_get_template_part, bbp_locate_template, load_template, require('/plugins/bbpress/templates/default/bbpress/content-single-topic.php'), bbp_breadcrumb, bbp_get_breadcrumb, bbp_get_page_by_path, get_page_by_path [3] => 1656377015.6457 [4] => Array ( ) ) [80] => Array ( [0] => SELECT SQL_CALC_FOUND_ROWS wp_posts.* FROM wp_posts FORCE INDEX (PRIMARY, post_parent) WHERE 1=1 AND (wp_posts.ID = 100000681 OR wp_posts.post_parent = 100000681) AND wp_posts.post_type IN ('topic', 'reply') AND (wp_posts.post_status = 'publish' OR wp_posts.post_status = 'closed') ORDER BY wp_posts.post_date ASC LIMIT 0, 25 [1] => 0.017458915710449 [2] => require('wp-blog-header.php'), require_once('wp-includes/template-loader.php'), apply_filters('template_include'), WP_Hook->apply_filters, bbp_template_include, apply_filters('bbp_template_include'), WP_Hook->apply_filters, bbp_template_include_theme_compat, BBP_Shortcodes->display_topic, bbp_get_template_part, bbp_locate_template, load_template, require('/plugins/bbpress/templates/default/bbpress/content-single-topic.php'), bbp_has_replies, WP_Query->__construct, WP_Query->query, WP_Query->get_posts [3] => 1656377015.7351 [4] => Array ( ) ) [81] => Array ( [0] => SELECT FOUND_ROWS() [1] => 0.00010991096496582 [2] => require('wp-blog-header.php'), require_once('wp-includes/template-loader.php'), apply_filters('template_include'), WP_Hook->apply_filters, bbp_template_include, apply_filters('bbp_template_include'), WP_Hook->apply_filters, bbp_template_include_theme_compat, BBP_Shortcodes->display_topic, bbp_get_template_part, bbp_locate_template, load_template, require('/plugins/bbpress/templates/default/bbpress/content-single-topic.php'), bbp_has_replies, WP_Query->__construct, WP_Query->query, WP_Query->get_posts, WP_Query->set_found_posts [3] => 1656377015.7528 [4] => Array ( ) ) [82] => Array ( [0] => SELECT post_id, meta_key, meta_value FROM wp_postmeta WHERE post_id IN (100000497) ORDER BY meta_id ASC [1] => 0.00028586387634277 [2] => require('wp-blog-header.php'), require_once('wp-includes/template-loader.php'), apply_filters('template_include'), WP_Hook->apply_filters, bbp_template_include, apply_filters('bbp_template_include'), WP_Hook->apply_filters, bbp_template_include_theme_compat, BBP_Shortcodes->display_topic, bbp_get_template_part, bbp_locate_template, load_template, require('/plugins/bbpress/templates/default/bbpress/content-single-topic.php'), bbp_get_template_part, bbp_locate_template, load_template, require('/plugins/bbpress/templates/default/bbpress/loop-replies.php'), bbp_get_template_part, bbp_locate_template, load_template, require('/plugins/bbpress/templates/default/bbpress/loop-single-reply.php'), bbp_reply_admin_links, bbp_get_reply_admin_links, bbp_get_topic_admin_links, bbp_get_topic_reply_link, bbp_current_user_can_access_create_reply_form, bbp_is_forum_open, bbp_is_forum_closed, bbp_is_forum_status, bbp_get_forum_status, get_post_meta, get_metadata, get_metadata_raw, update_meta_cache [3] => 1656377015.7927 [4] => Array ( ) ) [83] => Array ( [0] => SELECT user_id FROM wp_usermeta WHERE meta_key = 'wp__bbp_moderator_ids' and FIND_IN_SET('100000497', meta_value) > 0 [1] => 0.00023293495178223 [2] => require('wp-blog-header.php'), require_once('wp-includes/template-loader.php'), apply_filters('template_include'), WP_Hook->apply_filters, bbp_template_include, apply_filters('bbp_template_include'), WP_Hook->apply_filters, bbp_template_include_theme_compat, BBP_Shortcodes->display_topic, bbp_get_template_part, bbp_locate_template, load_template, require('/plugins/bbpress/templates/default/bbpress/content-single-topic.php'), bbp_get_template_part, bbp_locate_template, load_template, require('/plugins/bbpress/templates/default/bbpress/loop-replies.php'), bbp_get_template_part, bbp_locate_template, load_template, require('/plugins/bbpress/templates/default/bbpress/loop-single-reply.php'), bbp_reply_class, bbp_get_reply_class, bbp_is_user_forum_moderator, user_can, WP_User->has_cap, map_meta_cap, apply_filters('map_meta_cap'), WP_Hook->apply_filters, bbp_map_meta_caps, apply_filters('bbp_map_meta_caps'), WP_Hook->apply_filters, bbp_map_primary_meta_caps, bbp_is_object_of_user, bbp_get_users_for_object, BBP_User_Engagements_User->get_users_for_object [3] => 1656377015.8072 [4] => Array ( ) ) [84] => Array ( [0] => SELECT wp_posts.* FROM wp_posts WHERE 1=1 AND wp_posts.post_parent = 100000681 AND wp_posts.post_type = 'revision' AND ((wp_posts.post_status = 'inherit')) ORDER BY wp_posts.post_date ASC, wp_posts.ID ASC [1] => 0.00033998489379883 [2] => require('wp-blog-header.php'), require_once('wp-includes/template-loader.php'), apply_filters('template_include'), WP_Hook->apply_filters, bbp_template_include, apply_filters('bbp_template_include'), WP_Hook->apply_filters, bbp_template_include_theme_compat, BBP_Shortcodes->display_topic, bbp_get_template_part, bbp_locate_template, load_template, require('/plugins/bbpress/templates/default/bbpress/content-single-topic.php'), bbp_get_template_part, bbp_locate_template, load_template, require('/plugins/bbpress/templates/default/bbpress/loop-replies.php'), bbp_get_template_part, bbp_locate_template, load_template, require('/plugins/bbpress/templates/default/bbpress/loop-single-reply.php'), bbp_reply_content, bbp_get_reply_content, apply_filters('bbp_get_reply_content'), WP_Hook->apply_filters, bbp_reply_content_append_revisions, bbp_get_reply_revision_log, bbp_get_topic_revision_log, bbp_get_topic_revisions, wp_get_post_revisions, get_children, get_posts, WP_Query->query, WP_Query->get_posts [3] => 1656377015.8626 [4] => Array ( ) ) [85] => Array ( [0] => SELECT post_id, meta_key, meta_value FROM wp_postmeta WHERE post_id IN (100000682) ORDER BY meta_id ASC [1] => 0.0001680850982666 [2] => require('wp-blog-header.php'), require_once('wp-includes/template-loader.php'), apply_filters('template_include'), WP_Hook->apply_filters, bbp_template_include, apply_filters('bbp_template_include'), WP_Hook->apply_filters, bbp_template_include_theme_compat, BBP_Shortcodes->display_topic, bbp_get_template_part, bbp_locate_template, load_template, require('/plugins/bbpress/templates/default/bbpress/content-single-topic.php'), bbp_get_template_part, bbp_locate_template, load_template, require('/plugins/bbpress/templates/default/bbpress/loop-replies.php'), bbp_get_template_part, bbp_locate_template, load_template, require('/plugins/bbpress/templates/default/bbpress/loop-single-reply.php'), bbp_reply_content, bbp_get_reply_content, apply_filters('bbp_get_reply_content'), WP_Hook->apply_filters, bbp_reply_content_append_revisions, bbp_get_reply_revision_log, bbp_get_topic_revision_log, bbp_get_topic_revisions, wp_get_post_revisions, get_children, get_posts, WP_Query->query, WP_Query->get_posts, update_post_caches, update_postmeta_cache, update_meta_cache [3] => 1656377015.8632 [4] => Array ( ) ) [86] => Array ( [0] => SELECT wp_posts.* FROM wp_posts WHERE 1=1 AND wp_posts.post_type = 'popup' AND (wp_posts.post_status = 'publish' OR wp_posts.post_status = 'closed') ORDER BY wp_posts.post_date DESC [1] => 0.00030803680419922 [2] => require('wp-blog-header.php'), require_once('wp-includes/template-loader.php'), include('/themes/aardvark/bbpress.php'), get_header, locate_template, load_template, require_once('/themes/aardvark-child/header.php'), wp_head, do_action('wp_head'), WP_Hook->do_action, WP_Hook->apply_filters, wp_enqueue_scripts, do_action('wp_enqueue_scripts'), WP_Hook->do_action, WP_Hook->apply_filters, popmake_preload_popups, WP_Query->__construct, WP_Query->query, WP_Query->get_posts [3] => 1656377016.1385 [4] => Array ( ) ) [87] => Array ( [0] => SELECT * FROM wp_posts WHERE ID = 100000058 LIMIT 1 [1] => 0.0001978874206543 [2] => require('wp-blog-header.php'), require_once('wp-includes/template-loader.php'), include('/themes/aardvark/bbpress.php'), get_header, locate_template, load_template, require_once('/themes/aardvark-child/header.php'), wp_head, do_action('wp_head'), WP_Hook->do_action, WP_Hook->apply_filters, wp_site_icon, has_site_icon, get_site_icon_url, wp_get_attachment_image_url, wp_get_attachment_image_src, image_downsize, wp_attachment_is_image, wp_attachment_is, get_post, WP_Post::get_instance [3] => 1656377016.4482 [4] => Array ( ) ) [88] => Array ( [0] => SELECT post_id, meta_key, meta_value FROM wp_postmeta WHERE post_id IN (100000058) ORDER BY meta_id ASC [1] => 0.00018787384033203 [2] => require('wp-blog-header.php'), require_once('wp-includes/template-loader.php'), include('/themes/aardvark/bbpress.php'), get_header, locate_template, load_template, require_once('/themes/aardvark-child/header.php'), wp_head, do_action('wp_head'), WP_Hook->do_action, WP_Hook->apply_filters, wp_site_icon, has_site_icon, get_site_icon_url, wp_get_attachment_image_url, wp_get_attachment_image_src, image_downsize, wp_attachment_is_image, wp_attachment_is, get_attached_file, get_post_meta, get_metadata, get_metadata_raw, update_meta_cache [3] => 1656377016.4487 [4] => Array ( ) ) [89] => Array ( [0] => SELECT option_value FROM wp_options WHERE option_name = 'wpb_js_not_responsive_css' LIMIT 1 [1] => 0.0001370906829834 [2] => require('wp-blog-header.php'), require_once('wp-includes/template-loader.php'), include('/themes/aardvark/bbpress.php'), get_header, locate_template, load_template, require_once('/themes/aardvark-child/header.php'), body_class, get_body_class, apply_filters('body_class'), WP_Hook->apply_filters, Vc_Base->bodyClass, js_composer_body_class, Vc_Settings::get, get_option [3] => 1656377016.5357 [4] => Array ( ) ) [90] => Array ( [0] => SELECT t.*, tt.* FROM wp_terms AS t INNER JOIN wp_term_taxonomy AS tt ON t.term_id = tt.term_id WHERE t.term_id = 42 [1] => 0.00025010108947754 [2] => require('wp-blog-header.php'), require_once('wp-includes/template-loader.php'), include('/themes/aardvark/bbpress.php'), get_header, locate_template, load_template, require_once('/themes/aardvark-child/header.php'), get_template_part, locate_template, load_template, require('/themes/aardvark/lib/sections/header/standard-header.php'), get_template_part, locate_template, load_template, require('/themes/aardvark/lib/sections/header/logo-left-1.php'), get_template_part, locate_template, load_template, require('/themes/aardvark/lib/sections/header/primary-nav.php'), wp_nav_menu, wp_get_nav_menu_object, get_term, WP_Term::get_instance [3] => 1656377016.7927 [4] => Array ( ) ) [91] => Array ( [0] => SELECT tr.object_id FROM wp_term_relationships AS tr INNER JOIN wp_term_taxonomy AS tt ON tr.term_taxonomy_id = tt.term_taxonomy_id WHERE tt.taxonomy IN ('nav_menu') AND tt.term_id IN ('42') ORDER BY tr.object_id ASC [1] => 0.00021886825561523 [2] => require('wp-blog-header.php'), require_once('wp-includes/template-loader.php'), include('/themes/aardvark/bbpress.php'), get_header, locate_template, load_template, require_once('/themes/aardvark-child/header.php'), get_template_part, locate_template, load_template, require('/themes/aardvark/lib/sections/header/standard-header.php'), get_template_part, locate_template, load_template, require('/themes/aardvark/lib/sections/header/logo-left-1.php'), get_template_part, locate_template, load_template, require('/themes/aardvark/lib/sections/header/primary-nav.php'), wp_nav_menu, wp_get_nav_menu_items, get_objects_in_term [3] => 1656377016.7933 [4] => Array ( ) ) [92] => Array ( [0] => SELECT wp_posts.* FROM wp_posts WHERE 1=1 AND wp_posts.ID IN (100000028,100000129,100000347,100000790,100000791,100000792,100000793,100001335,100001338,100001340,100001341,100001342,100001343,100001344,100001345,100001346,100001347,100001348,100001349,100001350,100001445,100002875,100004859) AND wp_posts.post_type = 'nav_menu_item' AND ((wp_posts.post_status = 'publish')) ORDER BY wp_posts.menu_order ASC [1] => 0.016708135604858 [2] => require('wp-blog-header.php'), require_once('wp-includes/template-loader.php'), include('/themes/aardvark/bbpress.php'), get_header, locate_template, load_template, require_once('/themes/aardvark-child/header.php'), get_template_part, locate_template, load_template, require('/themes/aardvark/lib/sections/header/standard-header.php'), get_template_part, locate_template, load_template, require('/themes/aardvark/lib/sections/header/logo-left-1.php'), get_template_part, locate_template, load_template, require('/themes/aardvark/lib/sections/header/primary-nav.php'), wp_nav_menu, wp_get_nav_menu_items, get_posts, WP_Query->query, WP_Query->get_posts [3] => 1656377016.7945 [4] => Array ( ) ) [93] => Array ( [0] => SELECT post_id, meta_key, meta_value FROM wp_postmeta WHERE post_id IN (100000790,100000028,100000791,100000129,100000792,100000793,100001335,100000347,100001338,100001340,100001342,100001445,100001341,100001343,100001344,100001345,100001346,100002875,100001347,100001348,100001349,100001350,100004859) ORDER BY meta_id ASC [1] => 0.00073385238647461 [2] => require('wp-blog-header.php'), require_once('wp-includes/template-loader.php'), include('/themes/aardvark/bbpress.php'), get_header, locate_template, load_template, require_once('/themes/aardvark-child/header.php'), get_template_part, locate_template, load_template, require('/themes/aardvark/lib/sections/header/standard-header.php'), get_template_part, locate_template, load_template, require('/themes/aardvark/lib/sections/header/logo-left-1.php'), get_template_part, locate_template, load_template, require('/themes/aardvark/lib/sections/header/primary-nav.php'), wp_nav_menu, wp_get_nav_menu_items, get_posts, WP_Query->query, WP_Query->get_posts, update_post_caches, update_postmeta_cache, update_meta_cache [3] => 1656377016.8129 [4] => Array ( ) ) [94] => Array ( [0] => SELECT wp_posts.* FROM wp_posts WHERE 1=1 AND wp_posts.ID IN (100000788,28,100000344,73,466,26,100001333,445) AND wp_posts.post_type = 'page' AND ((wp_posts.post_status = 'publish')) ORDER BY wp_posts.post_date DESC [1] => 0.00035691261291504 [2] => require('wp-blog-header.php'), require_once('wp-includes/template-loader.php'), include('/themes/aardvark/bbpress.php'), 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dynamic_sidebar, WP_Widget->display_callback, BBP_Topics_Widget->widget, WP_Query->__construct, WP_Query->query, WP_Query->get_posts [3] => 1656377017.1164 [4] => Array ( ) ) [102] => Array ( [0] => SELECT wp_posts.* FROM wp_posts WHERE ID IN (100005079,100005078,100005077,100005076,100005075) [1] => 0.00019502639770508 [2] => require('wp-blog-header.php'), require_once('wp-includes/template-loader.php'), include('/themes/aardvark/bbpress.php'), get_sidebar, locate_template, load_template, require_once('/themes/aardvark/sidebar-right.php'), dynamic_sidebar, WP_Widget->display_callback, BBP_Topics_Widget->widget, WP_Query->__construct, WP_Query->query, WP_Query->get_posts, _prime_post_caches [3] => 1656377017.1172 [4] => Array ( ) ) [103] => Array ( [0] => SELECT * FROM wp_users WHERE ID = '11519' LIMIT 1 [1] => 0.0001521110534668 [2] => require('wp-blog-header.php'), require_once('wp-includes/template-loader.php'), include('/themes/aardvark/bbpress.php'), get_sidebar, locate_template, 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WP_Widget->display_callback, BBP_Topics_Widget->widget, WP_Query->the_post, WP_Query->setup_postdata, WP_Query->generate_postdata, get_userdata, get_user_by, WP_User->init, WP_User->for_site, WP_User->get_caps_data, get_user_meta, get_metadata, get_metadata_raw, update_meta_cache [3] => 1656377017.1365 [4] => Array ( ) ) [107] => Array ( [0] => SELECT * FROM wp_users WHERE ID = '11535' LIMIT 1 [1] => 0.00015020370483398 [2] => require('wp-blog-header.php'), require_once('wp-includes/template-loader.php'), include('/themes/aardvark/bbpress.php'), get_sidebar, locate_template, load_template, require_once('/themes/aardvark/sidebar-right.php'), dynamic_sidebar, WP_Widget->display_callback, BBP_Topics_Widget->widget, WP_Query->the_post, WP_Query->setup_postdata, WP_Query->generate_postdata, get_userdata, get_user_by, WP_User::get_data_by [3] => 1656377017.1376 [4] => Array ( ) ) [108] => Array ( [0] => SELECT user_id, meta_key, meta_value FROM wp_usermeta WHERE user_id IN (11535) ORDER BY umeta_id ASC [1] => 0.00021195411682129 [2] => require('wp-blog-header.php'), require_once('wp-includes/template-loader.php'), include('/themes/aardvark/bbpress.php'), get_sidebar, locate_template, load_template, require_once('/themes/aardvark/sidebar-right.php'), dynamic_sidebar, WP_Widget->display_callback, BBP_Topics_Widget->widget, WP_Query->the_post, WP_Query->setup_postdata, WP_Query->generate_postdata, get_userdata, get_user_by, WP_User->init, WP_User->for_site, WP_User->get_caps_data, get_user_meta, get_metadata, get_metadata_raw, update_meta_cache [3] => 1656377017.138 [4] => Array ( ) ) [109] => Array ( [0] => SELECT * FROM wp_users WHERE ID = '11540' LIMIT 1 [1] => 0.0001530647277832 [2] => require('wp-blog-header.php'), require_once('wp-includes/template-loader.php'), include('/themes/aardvark/bbpress.php'), get_sidebar, locate_template, load_template, require_once('/themes/aardvark/sidebar-right.php'), dynamic_sidebar, WP_Widget->display_callback, BBP_Topics_Widget->widget, WP_Query->the_post, WP_Query->setup_postdata, WP_Query->generate_postdata, get_userdata, get_user_by, WP_User::get_data_by [3] => 1656377017.1521 [4] => Array ( ) ) [110] => Array ( [0] => SELECT user_id, meta_key, meta_value FROM wp_usermeta WHERE user_id IN (11540) ORDER BY umeta_id ASC [1] => 0.00022792816162109 [2] => require('wp-blog-header.php'), require_once('wp-includes/template-loader.php'), include('/themes/aardvark/bbpress.php'), get_sidebar, locate_template, load_template, require_once('/themes/aardvark/sidebar-right.php'), dynamic_sidebar, WP_Widget->display_callback, BBP_Topics_Widget->widget, WP_Query->the_post, WP_Query->setup_postdata, WP_Query->generate_postdata, get_userdata, get_user_by, WP_User->init, WP_User->for_site, WP_User->get_caps_data, get_user_meta, get_metadata, get_metadata_raw, update_meta_cache [3] => 1656377017.1525 [4] => Array ( ) ) [111] => Array ( [0] => SELECT post_id, meta_key, meta_value FROM wp_postmeta WHERE post_id IN (100000131) ORDER BY meta_id ASC [1] => 0.00018000602722168 [2] => require('wp-blog-header.php'), require_once('wp-includes/template-loader.php'), include('/themes/aardvark/bbpress.php'), get_sidebar, locate_template, load_template, require_once('/themes/aardvark/sidebar-right.php'), dynamic_sidebar, WP_Widget->display_callback, bps_widget->widget, bps_display_form, bps_call_form_template, bps_meta, get_post_meta, get_metadata, get_metadata_raw, update_meta_cache [3] => 1656377017.1542 [4] => Array ( ) ) [112] => Array ( [0] => SELECT t.*, tt.* FROM wp_terms AS t INNER JOIN wp_term_taxonomy AS tt ON t.term_id = tt.term_id WHERE tt.taxonomy IN ('bp_member_type') ORDER BY t.name ASC [1] => 0.00086188316345215 [2] => require('wp-blog-header.php'), require_once('wp-includes/template-loader.php'), include('/themes/aardvark/bbpress.php'), get_sidebar, locate_template, load_template, require_once('/themes/aardvark/sidebar-right.php'), dynamic_sidebar, WP_Widget->display_callback, 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include('/themes/aardvark/buddypress/members/bps-form-default.php'), bps_escaped_form_data, bps_escaped_form_data49, bps_get_form_fields, bps_get_fields, apply_filters('bps_add_fields'), WP_Hook->apply_filters, bps_xprofile_setup, bp_has_profile, BP_XProfile_Data_Template->__construct, bp_xprofile_get_groups, BP_XProfile_Group::get, BP_XProfile_Group::get_group_ids [3] => 1656377017.1754 [4] => Array ( ) ) [114] => Array ( [0] => SELECT * FROM wp_bp_xprofile_groups WHERE id IN (1,2) ORDER BY FIELD( id, 1,2 ) [1] => 0.00018191337585449 [2] => require('wp-blog-header.php'), require_once('wp-includes/template-loader.php'), include('/themes/aardvark/bbpress.php'), get_sidebar, locate_template, load_template, require_once('/themes/aardvark/sidebar-right.php'), dynamic_sidebar, WP_Widget->display_callback, bps_widget->widget, bps_display_form, bps_call_form_template, include('/themes/aardvark/buddypress/members/bps-form-default.php'), bps_escaped_form_data, bps_escaped_form_data49, bps_get_form_fields, bps_get_fields, apply_filters('bps_add_fields'), WP_Hook->apply_filters, bps_xprofile_setup, bp_has_profile, BP_XProfile_Data_Template->__construct, bp_xprofile_get_groups, BP_XProfile_Group::get, BP_XProfile_Group::get_group_data [3] => 1656377017.1882 [4] => Array ( ) ) [115] => Array ( [0] => SELECT id FROM wp_bp_xprofile_fields WHERE group_id IN ( 1,2 ) AND parent_id = 0 ORDER BY field_order [1] => 0.00020813941955566 [2] => require('wp-blog-header.php'), require_once('wp-includes/template-loader.php'), include('/themes/aardvark/bbpress.php'), get_sidebar, locate_template, load_template, require_once('/themes/aardvark/sidebar-right.php'), dynamic_sidebar, WP_Widget->display_callback, bps_widget->widget, bps_display_form, bps_call_form_template, include('/themes/aardvark/buddypress/members/bps-form-default.php'), bps_escaped_form_data, bps_escaped_form_data49, bps_get_form_fields, bps_get_fields, apply_filters('bps_add_fields'), WP_Hook->apply_filters, 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